Systemic lupus erythematosus sle, or lupus, is an autoimmune disease that causes damage to various organs or cells of the body. Pathogenesis 20 and clinical features 1 introduction systemic lupus erythematosus sle is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues. Systemic lupus erythematosus sle is an autoimmune disease. Systemic lupus erythematosus and the antiphospholipid syndrome bonnie l. Systemic lupus erythematosus page 1 systemic lupus erythematosus lupus systemic lupus erythematosus, referred to as sle or lupus, is sometimes called the great imitator. These criteria were developed and validated for the classification of patients with a longstanding established disease. Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat. Many drugs for the treatment of sle are in various stages of development. Lupus systemic lupus erythematosus emedicinehealth. The diagnosis and treatment of systemic lupus erythematosus. Aug 21, 20 systemic lupus erythematosus sle is a complex autoimmune disease and occurs worldwide in both children and adults.
The 2012 revised slicc criteria for classification of. Systemic lupus erythematosus sle is the prototypical systemic autoimmune disease and is characterized by a clinical course of flares and remissions. Performance of the 2012 systemic lupus international collaborating clinics classification criteria versus the 1997 american college of rheumatology classification criteria in adult and juvenile systemic lupus erythematosus. Systemic lupus erythematosus sle is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue. Bermas, md brigham and womens hospital conflict of interest disclosures. The slicc group is an international group of investigators dedicated to clinical research on sle. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and. It is suitable for basic scientists looking for detailed coverage of their areas of interest. Belimumab is a newer therapy which is licensed for addon therapy in adults with active. In this disease, the immune system of the body mistakenly attacks healthy tissue. Systemic lupus erythematosus, clinical features and diagnosis. Lack of availability of suitable treatments or treatments that are only symptomatic calls for.
The types of lupus systemic lupus erythematosus sle or lupus any organ cutaneousdiscoidskin lupus skin only druginduced medications cause mixed connective tissue disease associated with other autoimmune diseases neonatal lupus affect infants of women with lupus. Systemic lupus erythematosus sle is a progressive autoimmune disease that results in inflammation and tissue damage characterized by flares, spontaneous remission, and relapses, sle is a chronic disease sle can affect any part of the body but often results in. Sle is a chronic autoimmune disease that can affect almost any organ system. Study of systemic lupus erythematosus the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Systemic lupus erythematosus sle, also known simply as lupus, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. Infections and systemic lupus erythematosus 49 einstein. The booklet describes the disease and its symptoms and contains information about diagnosis and treatment as well as current. Symptoms vary between people and may be mild to severe. It is a valuable clinical resource for practicing clinicians from different disciplines. American college of rheumatology guidelines for screening, treatment, and management of lupus nephritis.
Systemic lupus erythematosus is a useful reference for specialists in the diagnosis and management of patients with sle, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. Development of a systemic lupus erythematosus cardiovascular. Systemic lupus systemic lupus erythematosus a multisystem autoimmune disease etiology unknown most common in women, young to most common in women, young to middleaged highly variable clinical presentation highly variable clinical presentation in individual patients harvardmit division of health sciences and technology. It has been considered the great imitator of many different diseases. Oct 01, 2012 acute kidney injury is defined as an abrupt within 48 hours reduction in kidney function based on an elevation in serum creatinine level, a reduction in urine output, the need for renal. Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the gladel cohort. Systemic lupus erythematosus clinical practice guideline. Objective accelerated atherosclerosis remains the major cause of late death after 5 years in sle. To describe the clinical outcome and safety of rituxim ab rtx treatment in systemic lupus erythematosus. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus.
Alarconsegovia d, alarconriquelme me, cardiel mh, et al. Systemic lupus erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with sle, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference. Systemic lupus erythematosus this booklet is for people who have systemic lupus erythematosus, commonly called sle or lupus, as well as for their family and friends and others who want to better understand the disease. Systemic lupus erythematosus is an autoimmune disease that promotes chronic inflammation, with periods of activation and remission. Dec, 2011 systemic lupus erythematosus commonly known as lupus is an intricate disorder with multiple organ involvement characterized primarily by inflammation caused due to deposition of immunecomplexes formed by production of autoantibodies against nuclear, nucleolar as well as cytoplasmic selfantigens.
Familial aggregation of systemic lupus erythematosus and. Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel etal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and. The signs and symptoms of sle vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous. The most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. We sought to construct a datadriven formula for cardiovascular risk in sle, based on data collected during the first year in a longitudinal cohort, for research purposes.
In 2012, the systemic lupus international collaborating clinics slicc revised and validated the acr criteria. In the slicc system, a patient must meet at least four. Disease severity is wide ranging, with most suffering milder. Flower c, hennis aj, hambleton ir, nicholson gd, liang mh. Systemic lupus erythematosus sle is a chronic inflammatory disease affecting a number of organs and organ systems 1,2. Systemic lupus erythematosus sle is an autoimmune disease with a strong genetic component and is characterized by chronic inflammation and the production of antinuclear autoantibodies. Listing a study does not mean it has been evaluated by the u. Physiopathology of pain in systemic erythematosus lupus.
Systemic lupus erythematosus australia pdf ppt case. The first classification criteria for sle were developed in 1971, revised in 1982, and adopted by the american college of rheumatology acr in 1997. Update on differences between childhoodonset and adultonset. Although both men and women of all age groups can be. The estimated annual incidence among children is 2. In the past, criteria developed by the american college of rheumatology in 1982 and revised in 1997 were used to classify sle. Yet, the traditional cardiovascular risk equations such as framingham consistently underestimate the risk. Therapeutic effect of withania somnifera on pristaneinduced. Study of systemic lupus erythematosus full text view. It can affect the skin, joints, kidneys, brain, and other organs. None overview diagnostic classification criteria of sle the many faces of sle a little bit about other forms of slecutaneous and drug induced treatment antiphospholipid. Systemic lupus erythematosus sle is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. Systemic lupus erythematosus genetics home reference nih. The disease has been studied in dogs as the animal model for sle in humans.
This book provides a comprehensive overview of the basic and clinical sciences of systemic lupus erythematosus. Barbados national lupus registry group systemic lupus erythematosus in an afrocaribbean population. This includes novel medications, as well as agents that are currently approved for other indications. It describes how advances in molecular biology have increased our understanding of this disease. The clinical course is variable, with a broad spectrum of organ manifestations.
Systemic lupus erythematosus may also occur in the form of periarticular inflammation that affects the tendon sheaths, the illness. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. Jun 16, 2016 systemic lupus erythematosus sle is an autoimmune disease that impacts many body systems, with a wide variety of signs and symptoms in each patient. In lupus, the bodys immune system, which normally functions to protect against foreign invaders, becomes. Facts to know about lupus systemic lupus erythematosus sle, or lupus, is an autoimmune disease in which a persons immune system attacks various organs or cells of the body, causing damage and dysfunction. The diagnostic accuracies of the 2012 slicc criteria and. Jun 19, 2015 systemic lupus erythematosus sle is an autoimmune disease with a prevalence of 36.